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TaggedAPTARAFigure TaggedAPTARAEnd260                                                          W. Chen et al.
                                                               with new-onset AT when compared with registration for a
                                                               marathon (Supplementary Table 3).TaggedAPTARAEnd


                                                               TaggedAPTARAH14. DiscussionTaggedAPTARAEnd
                                                                  TaggedAPTARAPThis is the first prospective cohort study on AT that sepa-
                                                               rately reports the proportion of insertional and midportion AT
                                                               as well as their risk factors. The incidence of AT in our study
                                                               was 4.2% during a mean follow-up of 20 weeks. The propor-
                                                               tion of insertional and midportion AT was 28% and 64%,
                                                               respectively, and 8% had a combined type of insertional and
         Fig. 3. Distribution of new-onset AT over time from registration for the event
                                                               midportion AT. Male participants and runners registering for a
         until the end of follow-up. The big dot on the horizontal axis marks the day of
                                                               marathon had the highest incidence of AT. AT in the past 12
         the event. AT = Achilles tendinopathy.TaggedAPTARAEnd
                                                               months showed the strongest association with new-onset AT;
                                                               this was also the risk factor with the strongest association for
         registration for a marathon. Higher age was significantly asso-  the subcategories, insertional and midportion AT. For devel-
         ciated with new-onset insertional AT (OR = 0.97, 95%CI:  oping new-onset AT, and specifically for midportion AT,
         0.941.00). Sensitivity analysis of the multivariate analysis in  registering for an event of 10/10.55 km resulted in a negative
         participants who completed all follow-up questionnaires  association with new-onset AT when compared with regis-
         showed similar results, except that registration for an event  tering for a marathon. Younger age was significantly associ-
         with a distance of 10/10.55 km had no significant association  ated with the onset of insertional AT.TaggedAPTARAEnd

         Table 3
         TaggedAPTARACaptionLogistic regression analyses of potential risk factors associated with new-onset AT and subcategories of AT.  TaggedAPTARAEnd
                                   New-onset AT (n = 141)        Insertional (n = 39)TaggedAPTARAEnd  Midportion (n = 90)TaggedAPTARAEndTaggedAPTARAEnd
                             UnivariateTaggedAPTARAEnd  MultivariateTaggedAPTARAEnd  UnivariateTaggedAPTARAEnd  MultivariateTaggedAPTARAEnd  UnivariateTaggedAPTARAEnd  MultivariateTaggedAPTARAEndTaggedAPTARAEndTaggedAPTARAEndTaggedAPTARATbody
         DemographicsTaggedAPTARAEnd                                                                TaggedAPTARAEnd
           Sex (male)TaggedAPTARAEnd  1.92 (1.302.85)**TaggedAPTARAEnd  1.65 (0.992.76)TaggedAPTARAEnd  2.11 (1.004.48)TaggedAPTARAEnd  2.14 (0.974.72)TaggedAPTARAEnd  1.96 (1.203.20)**TaggedAPTARAEnd 1.49 (0.902.50)TaggedAPTARAEndTaggedAPTARAEnd
           Age (year)TaggedAPTARAEnd  1.00 (0.991.02)TaggedAPTARAEnd  0.98 (0.951.00)TaggedAPTARAEnd  0.97 (0.941.00)*TaggedAPTARAEnd  1.01 (0.991.03)TaggedAPTARAEnd  TaggedAPTARAEnd
           Weight (kg)TaggedAPTARAEnd  1.01 (1.001.03)TaggedAPTARAEnd  1.00 (0.981.02)TaggedAPTARAEnd  1.01 (0.981.04)TaggedAPTARAEnd  1.01 (0.991.03)TaggedAPTARAEnd  TaggedAPTARAEnd
           SQUASHTaggedAPTARAEnd  1.00 (1.001.00)TaggedAPTARAEnd  1.00 (1.001.00)TaggedAPTARAEnd  1.00 (1.001.00)TaggedAPTARAEnd  TaggedAPTARAEnd
         TrainingTaggedAPTARAEnd                                                                    TaggedAPTARAEnd
           Years of training (years)TaggedAPTARAEnd  1.01 (1.001.03)TaggedAPTARAEnd  1.00 (0.991.02)TaggedAPTARAEnd  0.98 (0.941.01)TaggedAPTARAEnd  1.02 (1.001.04)TaggedAPTARAEnd  1.01 (0.991.03)TaggedAPTARAEndTaggedAPTARAEnd
           MYDRTaggedAPTARAEnd  1.02 (0.931.12)TaggedAPTARAEnd  0.78 (0.481.28)TaggedAPTARAEnd  1.04 (0.961.13)TaggedAPTARAEnd  TaggedAPTARAEnd
           MYSRTaggedAPTARAEnd  0.37 (0.026.33)TaggedAPTARAEnd  0.97 (0.921.02)TaggedAPTARAEnd  1.00 (0.971.04)TaggedAPTARAEnd  TaggedAPTARAEnd
           Use of training schedule  1.15 (0.801.66)TaggedAPTARAEnd  0.65 (0.341.23)TaggedAPTARAEnd  0.61 (0.311.20)TaggedAPTARAEnd  1.63 (1.002.63)*TaggedAPTARAEnd  1.33 (0.792.22)TaggedAPTARAEndTaggedAPTARAEnd
           (yes)TaggedAPTARAEnd
           Running 80% on paved  0.83 (0.561.23)TaggedAPTARAEnd  1.86 (0.724.8)TaggedAPTARAEnd  1.75 (0.674.60)TaggedAPTARAEnd  0.85 (0.521.39)TaggedAPTARAEnd  TaggedAPTARAEnd
           road (yes)TaggedAPTARAEnd
           Use of compression socks  1.32 (0.881.97)TaggedAPTARAEnd  0.92 (0.601.41)TaggedAPTARAEnd  1.07 (0.492.35)TaggedAPTARAEnd  1.43 (0.882.32)TaggedAPTARAEnd  0.94 (0.561.59)TaggedAPTARAEndTaggedAPTARAEnd
           (yes)TaggedAPTARAEnd
         Landing typeTaggedAPTARAEnd                                                                TaggedAPTARAEnd
           HindfootTaggedAPTARAEnd  ReferenceTaggedAPTARAEnd  ReferenceTaggedAPTARAEnd  ReferenceTaggedAPTARAEnd  TaggedAPTARAEnd
           MidfootTaggedAPTARAEnd  0.90 (0.581.38)TaggedAPTARAEnd  1.57 (0.703.53)TaggedAPTARAEnd  0.75 (0.441.30)TaggedAPTARAEnd  TaggedAPTARAEnd
           ForefootTaggedAPTARAEnd  0.72 (0.391.30)TaggedAPTARAEnd  0.92 (0.292.95)TaggedAPTARAEnd  0.65 (0.301.37)TaggedAPTARAEnd  TaggedAPTARAEnd
           UnknownTaggedAPTARAEnd  0.88 (0.561.37)TaggedAPTARAEnd  1.14 (0.472.75)TaggedAPTARAEnd  0.92 (0.541.57)TaggedAPTARAEnd  TaggedAPTARAEnd
         Event distanceTaggedAPTARAEnd                                                              TaggedAPTARAEnd
           10/10.55 kmTaggedAPTARAEnd  0.50 (0.310.81)**TaggedAPTARAEnd  0.59 (0.360.97)*TaggedAPTARAEnd  0.84 (0.391.78)TaggedAPTARAEnd  0.86 (0.381.95)TaggedAPTARAEnd  0.37 (0.190.72)**TaggedAPTARAEnd 0.47 (0.230.93)*TaggedAPTARAEndTaggedAPTARAEnd
           15/16.1 kmTaggedAPTARAEnd  0.63 (0.371.07)TaggedAPTARAEnd  0.62 (0.351.08)TaggedAPTARAEnd  0.70 (0.261.87)TaggedAPTARAEnd  0.64 (0.231.77)TaggedAPTARAEnd  0.57 (0.291.14)TaggedAPTARAEnd  0.59 (0.291.21)TaggedAPTARAEndTaggedAPTARAEnd
           Half marathonTaggedAPTARAEnd  0.63 (0.371.07)TaggedAPTARAEnd  0.65 (0.381.13)TaggedAPTARAEnd  0.28 (0.071.2)TaggedAPTARAEnd  0.28 (0.071.22)TaggedAPTARAEnd  0.86 (0.481.54)TaggedAPTARAEnd  0.94 (0.511.72)TaggedAPTARAEndTaggedAPTARAEnd
           MarathonTaggedAPTARAEnd  ReferenceTaggedAPTARAEnd  ReferenceTaggedAPTARAEnd  ReferenceTaggedAPTARAEnd  ReferenceTaggedAPTARAEnd  ReferenceTaggedAPTARAEnd  ReferenceTaggedAPTARAEndTaggedAPTARAEnd
         Previous injuriesTaggedAPTARAEnd                                                           TaggedAPTARAEnd
           AT in the previous 12  6.71 (4.5010.02)**TaggedAPTARAEnd 6.47 (4.279.81)**TaggedAPTARAEnd 5.10 (2.4310.71)**TaggedAPTARAEnd 5.45 (2.5111.81)**TaggedAPTARAEnd 7.40 (4.611.89)**TaggedAPTARAEnd 6.96 (4.2411.40)**TaggedAPTARAEndTaggedAPTARAEnd
           months (yes)TaggedAPTARAEnd
           An RRI, except AT, in the  1.15 (0.811.64)TaggedAPTARAEnd  1.04 (0.542.01)TaggedAPTARAEnd  1.07 (0.691.66)TaggedAPTARAEnd  TaggedAPTARAEndTaggedAPTARAEnd
           previous 12 months (yes)TaggedAPTARAEnd
         Notes: Data are presented as OR (95%CI). The combined type of AT is not included in this analysis due to the low number of cases in this subclassification. Only
         variables with p < 0.20 in univariate analyses were entered in the multivariate model.
         * p < 0.05, ** p < 0.01.TaggedAPTARAEnd
         Abbreviations: 95%CI = 95% confidence interval; AT = Achilles tendinopathy; MYDR = month:year distance ratio; MYSR = month:year speed ratio; OR = odds
         ratio; RRI = running-related injury; SQUASH = the Short Questionnaire to Assess Health.TaggedAPTARAEnd
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